Israeli Prime Minister Benjamin Netanyahu is set to outline his policy for the Middle East peace process in a major speech, officials say.
Defence Minister Ehud Barak said the speech would be "cautious and vague", according to Army radio.
Mr Netanyahu has come under pressure from the US to back a two-state peace solution with the Palestinians.
He is also expected to respond to the re-election of Iran's hardline president Mahmoud Ahmadinejad.
Mr Ahmadinejad has in the past called for Israel to be wiped off the map, though the precise translation of his remarks is disputed.
Mr Netanyahu has previously called Iran the greatest threat to Israel since its creation in 1948.
Since becoming prime minister three months ago, Mr Netanyahu has stopped short of endorsing the creation of a sovereign Palestinian state.
His foreign minister has however backed the 2002 Middle East peace "roadmap", a peace plan signed by Israel and the Palestinians, which envisions an eventual two-state solution contingent on both sides fulfilling commitments at various stages.
There is speculation in Israel that Mr Netanyahu will base his comments on this document.
In his speech at Bar-Ilan university on Sunday "the prime minister intends to articulate a clear view as to how he wants to move forward in the peace process with the Palestinians," said Mark Regev, Mr Netanyahu's spokesman, quoted by Reuters news agency.
"His vision is to move forward towards a historic reconciliation, and it is clear that all parties must play a role if this process is to succeed."
Mr Netanyahu has in the past proposed focusing on economic, security and political relations, rather than territorial issues with the Palestinians.
The issue of settlements may form part of Mr Netanyahu's speech
The BBC's Paul Wood in Jerusalem says Mr Netanyahu has been reluctant to embrace the two-state solution and may try to appease the Americans with something else - removing Jewish settlement outposts that are illegal even under Israeli law.
The Palestinian Authority says it will not return to negotiations unless Israel freezes settlement activity in the West Bank and openly backs a two-state solution to the Israeli-Palestinian conflict.
Mr Netanyahu's proposals in his speech, explained to US envoy George Mitchell and other diplomats last week, are not expected to be adequate, one US official has said.
US President Barack Obama, in a keynote speech in Cairo on 4 June, described the Palestinians' situation under exile in neighbouring countries and under Israeli occupation as "intolerable".
"Israelis must acknowledge that just as Israel's right to exist cannot be denied, neither can Palestine's," Mr Obama said.
He also said the US bonds with Israel were "unbreakable".
Mr Mitchell, Mr Obama's Middle East envoy, has since been touring the region, visiting Israel, the West Bank, Egypt, Jordan and Syria.